Monkey D. Luffy is a tough opponent to deal with. He's got years of combat experience, and his skills include moving beyond light speed by thousands of times which is incredible. He's immune to blunt force attacks because of his rubber body making him nigh indestructible. Moreover, he can destroy mountains and islands just by throwing a punch. His conquerors and observation haki are also some of the strongest ever. Whereas, Gojo Satoru only has limited cursed techniques and his BIQ and IQ are incomparable with that of Luffy. Therefore, in a battle between Monkey D. Luffy and Gojo Satoru, Luffy will win because of his superior physical strength, speed, and combat experience.